REMEDIUM

Currently, physicians, researchers, scientific societies and health authorities are interested in evaluating the benefits, efficacy and safety of various ingredients and their various combinations, medical technologies and experience, as well as standardizing mesotherapy protocols and ingredients for use in the field of prevention, treatment and rehabilitation. In cosmetology and aesthetic medicine, indications for the use of mesotherapy are the need to dissolve fat, various skin conditions, alopecia, skin aging, lipolysis, pigmentation, cellulite, etc. The mesotherapy method uses products that are completely biocompatible and absorbable, a variety of techniques are used in mesotherapy, including less invasive needleless and microneedle. Despite the fact that mesotherapy is considered an effective technique, the issues of standardizing the methodology and dosing regimen, as well as determining the correct indications in clinical practice, remain unresolved. Further research is needed to evaluate the benefits, efficacy and safety of various ingredients and their various combinations (dose, frequency of administration, efficacy and safety), medical technology and experience, and the clinical role of mesotherapy in different applications. Research is required on the mechanisms of action of mesotherapy in combination with standard treatment methods, further development of products for complete facial rejuvenation. In the field of cell therapy and for parenteral drug delivery, the mechanisms of transdermal delivery of agents using various devices, their stability, efficacy, sterility, cytotoxicity, general toxicity, and skin sensitization require further study. In the study of microneedling, further research is needed to substantiate the therapeutic effect, the use of various methods, including pneumatic injections, nanochips, fractional microneedling. With volumizing procedures, it is necessary to understand the synergistic effect of different mesotherapy techniques, the properties of various fillers, their safety and effectiveness. More research is needed in the field of molecular diagnostic methods for early treatment of pathogenesis and prevention of infection during mesotherapy. Of particular importance is the problem of assessing the safety level of mesotherapy and determining standardized therapy parameters to minimize the risk of potential adverse reactions. At the same time, mesotherapy, as a method that gives a systemic sparing effect, can be synergized with other pharmacological or non-pharmacological methods of treatment.

Changes in political and economic conditions can inevitably affect various sectors of industry, including pharmaceutical. For the pharmaceutical industry, one of the significant risks in the context of changing cooperative and logistical relationships is geopolitical, characterized by the complexity of forecasting commodity-money relationships and the threat of reducing the level of safety and effectiveness of the drugs being traded. An analysis of global data has shown that the application of economic sanctions can lead to supply difficulties, which leads to defects in medicines and medical products on the national pharmaceutical market. Changing permanent suppliers, turning to less reliable sources of raw materials and materials can increase the risk of reducing the effectiveness of drugs and an increase in the number of adverse drug reactions.The article presents a model of the impact of new geopolitical risks on the Russian pharmaceutical market and the role of pharmacovigilance at a pharmaceutical enterprise to minimize this risk. The proposed theoretical model defines the improvement of the pharmacovigilance system at a pharmaceutical enterprise as a vector of minimizing geopolitical risk and developing a pharmaceutical quality system.

Introduction. At the end of 2019, an outbreak of coronavirus infection occurred in the People's Republic of China, which rapidly grew into a pandemic, affecting all countries. Doctors found themselves in a situation where it was necessary to apply all their skills and knowledge to “fight” the pandemic, putting their lives at risk.Purpose of the study. Study the emotional status of health workers affected by coronavirus infection.Patients and methods. The study involved 126 people: employees of a children's clinical hospital aged 19 to 65 years who suffered from COVID-19. Analysis of verbal responses, vegetative nervous system status, pantomimics and micro-expressions to control questions was conducted.Results. For control questions, the majority of respondents had hyperstick-hyperstick in 111 people, yawning in 13 people studied. Sweating - 15 people. A large number of discriminators were noted (licking and snacking on the red border of the lips, please drink) for 108 people. Pale facial skin was found in 33 respondents. Swelling, changes in the timbre of the voice to high, occurred in 115 subjects. Gestures-adapters (stroking the knees, hands, in the area of the jugular depression, the occipital part of the neck) were noted in 117 counselors. Gestures-manipulators (with phones, jewelry, clothing decor) for 70 interviewees. Strong micro-expressions of fear were not revealed, they prevailed in mild form in 108, less often in average - 15. In some cases, emotion was hidden by a neutral expression.Conclusion. Already, the work of psychologists of medical institutions should be aimed at correcting and psychotherapy of emotional disorders (fear), which will disguise themselves as panic attacks and syndromes of vegetative disorders in patients who have suffered COVID-19.

The result of the health care system is to improve the health indicators of the population, reduce the incidence rate and increase life expectancy. It becomes relevant to identify the regions that, with relatively insignificant financial costs for health care, were able to achieve the most significant results, both in the health care system and in the organization of drug provision. The article describes the essence and methodology of the Min-Max method, the main stages of the comparative analysis of the regional health care system and the organization of drug supply, allowing to assess and select the regions with the highest efficiency indicators and use their experience to organize medical care and improve the drug supply system.

The article presents a pharmacoeconomical study of treatment regimens for type 1 and type 2 diabetes mellitus in outpatient settings. Direct medical, direct non-medical and indirect costs were analyzed. Within the framework of direct medical costs, the cost of drug therapy, the cost of laboratory and instrumental research methods, the cost of providing services by medical professionals were considered. To calculate direct medical costs, we analyzed education in diabetes schools, undergoing sanatorium treatment. Indirect costs included payments of disability benefits, payments on temporary disability sheets. The data obtained formed the basis for the analysis of the «cost of the disease».

The article presents a review of foreign literature on health risks in the lifestyle of students in the context of the COVID-19 pandemic. Many researchers in their work show a significant impact of COVID-19 on the socio-economic factors of students' life, which in turn affects their health. In the lifestyle of students during the pandemic, such negative trends as malnutrition, low physical activity, depressive syndromes, and psychological status disorders have become highly prevalent. These circumstances contributed to the decrease in overall indicators of satisfaction with the quality of life among students.

The article considers the conditions for the development of marketing activities to promote a tourist destination, or a medical organization in the medical tourism market. The main indicators of the development of the industry, the most popular directions of medical tourist trips are noted. The factors contributing to marketing activity to ensure the popularity of subjects exporting medical services are highlighted.

The article uses materials of congresses of Pirogov society and railway physicians to consider main problems of Russian railroads medicine provision at the turn of 19-20th century. It is shown that the main attention of doctors was focused on solution of organizational problems and infrastructural deficits of medicines, pharmacies, pharmacists and others.