REMEDIUM

The article presents data on the results of a study of the pharmaceutical market of the Russian Federation of anti-burn OTC drugs for external use included in the State Register of Medicines. A classification of pharmaceutical care measures is proposed depending on the degree of skin damage within the framework of responsible self-treatment. According to the results of the content analysis, the structure of the Internet assortment of ATX-groups of OTC drugs for local treatment of burns is reflected. The results of the analysis of the range of OTC drugs for use depending on the degree of thermal burn are presented.

In accordance with the Agreement on Uniform Principles and Rules for the Circulation of Medicines within the Eurasian Economic Union dated December 23, 2014, starting in 2026, the circulation of medicines in the territory of all EAEU member states: Russia, Belarus, Kazakhstan, Kyrgyzstan and Armenia, will be governed by supranational legal acts and norms of the Union. In order not to lose sales markets, domestic pharmaceutical manufacturers must, by December 31, 2025, bring all registration dossiers for drugs registered earlier to comply with the requirements of the Union, and obtain registration certificates in the EAEU format. The article analyzes the amount of work that needs to be done to bring one registration dossier for a medicinal product in line with the Union's requirements, presents the time costs and the main emphasis is on a project-based approach to solving the problem of transition to the EAEU legal norms.

Introduction. In the context of the need increasing the efficiency of resource use, the development of day hospitals is an urgent task of Russian healthcare. In 2016-2021, the volume of planned medical care in day hospitals per 1 insured increased by 5.43%, and the tariff doubled. There is a strong opinion among specialists about the high medical and economic efficiency of day hospitals. However, the imperfection of the principles of financing day hospitals, regulatory documents regulating the work of day hospitals, weak integration and coordination of polyclinics and hospitals significantly reduce the efficiency of day hospitals.The aim of our research is to analyze and evaluate problems in the organization of day hospitals.Materials and methods. The study was conducted on the basis of the Kazan City Clinical Hospital No. 2 of the Ministry of Health of the Republic of Tatarstan. The study was conducted retrospectively according to medical records for 2017-2019. The number of cases of medical care in day hospitals included in the study was 6,877. Various methods of mathematical statistics were used in the course of the study.Results. Mostly, the referral for treatment in day hospitals was made out by district therapists. More patients were admitted to day hospitals on the basis of a round-the-clock hospital in October, July, September and April, and to day hospitals at the polyclinic in November, March and February. In the day hospital on the basis of a round-the-clock hospital, 73.5% of hospitalizations were carried out from Monday to Wednesday, and in the day hospital at the polyclinic even 80.4%. On Saturdays, hospitalization did not exceed 0.4% in a day hospital on the basis of a round-the-clock hospital and 1.9% on the basis of a polyclinic. On Sundays, patients were not hospitalized in day hospitals of the medical organization. The study of medical records showed that in a third of female patients and 42.7% of male patients, data on prehospital examinations were not included in the medical history or they were not carried out. Medical supervision on Saturdays and Sundays was not organized in 20% of cases of providing medical care to patients in a day hospital with a 24-hour hospital and 9% of cases in day hospitals on the basis of polyclinics. Examinations of the head of the department were not carried out in 82% of cases in day hospitals at polyclinics. On Sundays, there are only isolated cases of discharge from day hospitals.

Introduction. An important item of expenditure of health facilities (HF) is the purchase of medicines, medical devices and other goods that are provided by pharmacies - structural divisions of the HF. The purpose of the work is to study the current state of the hospital pharmacies in Russia.Materials and methods. To collect data on hospital pharmacies in Russia, an online questionnaire was conducted using an online questionnaire we developed, which consisted of 78 questions. Responses were received from 233 HF in 65 Federal subjects of the Russian Federation of all federal districts.Results. The median number of beds in the HF served by the pharmacy is 308, and the median commodity circulation is 48 million rubles. Only 27.9% of hospital pharmacies of the Moscow Region have a license for the manufacture of drugs, and 21.9% - for the manufacture of sterile drugs. About 20% of hospital pharmacies have departments in their structure. It was found that the value of the area of the hospital pharmacies is directly proportional to the number of HF beds (r = 0.564) and the value of commodity circulation in monetary terms (r = 0.425). The range of products of the hospital pharmacy is represented by medicines, medical devices for treatment, medical devices for diagnostics and disinfectants, which requires special competencies for competent planning and procurement. The most common positions are the head of a pharmacy, a pharmacist and a pharmacist-technologist. Median occupancy rates in absolute terms (4.0) and the number of pharmaceutical workers employed per 100 beds (1.2) may indicate an unmet need for staff, which is confirmed by data on a shortage of specialists in more than 60% of HF and the value of the actual deficit rates (more than 15%) in the absence of current staffing standards. Personnel aging continues, and its renewal on the part of university graduates is difficult. The need for updating the legal regulation of the activities of pharmacies of the Moscow Region is demonstrated.

Objective. To assess the feasibility of using the ATC/DDD methodology to predict the needs for genetically engineered biological drugs on the model of a republican hospital of the third level.Materials and methods. Medical documents (3329 patient health records with rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis during 2015-2020 years; 1181 appointment sheets) were used in our research. Retrospective and frequency analyses were used for learning of actual consumption of genetically engineered biological drugs (GIBD). Requirements on one case and for 355 predicted cases are calculated with the ATC/DDD methodology in natural unit of measurement (mg).Results and discussion. The frequency of appointments of 6 INN GIBP for 2019 has been established. The number of cases of the use of GIBP for 2020 is predicted - 355 cases. The forecast of the annual demand for GIBP in natural indicators (mg) and packages was obtained, which was compared with the actual consumption of GIBP for 2020.Conclusion. Based on the established discrepancies between the actual and predicted consumption of GIBD using ATC/DDD analysis for 4 INN, the discrepancy exceeded the criterion value of 25% (Abatacept - 62.33%, Infliximab - 73.35%, Rituximab - 68.42%, Certolizumab pegol - 38.63%), which indicates that it is inappropriate to use this method to predict the hospital need for GIBD.

The authors studied the world experience in the prevalence of various clinical manifestations of iron deficiency conditions and made an attempt to generalize their etiological data. The article deals with the issues of latent iron deficiency, and describes the scenarios for the development of absolute and functional deficiencies in iron deficiency anemia. Particular attention is paid to the search for scientific sources reporting on the influence of psychological factors on the occurrence and development of iron deficiency conditions.

The rapid increase in the consumption of medical products in various regions of the world driven by demographic processes, emergencies and globalization of development and production processes result in a series of threats and challenges to states in relation to ensuring control of safety and quality. No country in the world, regardless of the level of economic development, is no longer able to provide the necessary level of control over imported medical products without the formation of stable mechanisms for exchanging information with the control and supervisory authorities of other countries, as well as supporting the implementation of advanced standards of regulating the circulation of these products. The convergence of regulations in certain spheres of activity of states in certain regions of the world has been a widespread trend in recent decades, especially with regard to health technologies. In this article, the author examines the features of health technologies regulation harmonization within the framework of regional integration associations in the European and African region to formulate recommendations for the implementation of similar approaches to the development of supranational regulation of the common markets in EAEU.

The article analyzes the activities of zemstvo and city public self-governments of the Russian Empire in the field of drug provision of the population. It is shown that in this area, municipalities, despite significant differences in the scale and organizational forms of their medical and social activities, had common tasks and solutions. This was due to the special conditions for the legal regulation of the pharmaceutical sector and the focus of the activities of municipalities on addressing public health issues. Zemstvos and cities were united by the struggle to obtain the pre-emptive right to open free pharmacies, to increase the availability of drug care. Modestly represented in the total mass of free pharmacies in Russia, it was the municipalities that bore the main burden of providing civilian hospitals with medicines. This prompted them to look for ways to optimize supply, developed contacts with foreign manufacturers of pharmaceutical products. The social and state priorities demonstrated by the zemstvos and cities during the First World War convinced the government of the expediency of the municipalization of the pharmacy business. However, the political events of the autumn of 1917 directed its development along a different path.