<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher">REMEDIUM</journal-id><journal-title-group><journal-title>REMEDIUM</journal-title></journal-title-group><issn publication-format="print">1561-5936</issn><issn publication-format="electronic">2658-3534</issn><publisher><publisher-name>Joint-Stock Company Chicot</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1404</article-id><article-id pub-id-type="doi">10.32687/1561-5936-2022-26-1-67-71</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review article</subject></subj-group></article-categories><title-group><article-title>Iron deficiency: epidemiological issues and association with patient psychological health</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Shulaev</surname><given-names>A. V.</given-names></name><bio></bio><email>-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Chernobrovkina</surname><given-names>G. I.</given-names></name><bio></bio><email>pozolina@list.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff id="aff-1">Kazan State Medical University</aff><aff id="aff-2">Higher School of Organization and Management of Health Care Moscow</aff><pub-date date-type="epub" iso-8601-date="2022-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2022</year></pub-date><volume>26</volume><issue>1</issue><fpage>67</fpage><lpage>71</lpage><history><pub-date date-type="received" iso-8601-date="2022-03-29"><day>29</day><month>03</month><year>2022</year></pub-date></history><permissions><copyright-statement>Copyright © 2022,</copyright-statement><copyright-year>2022</copyright-year></permissions><abstract>The authors studied the world experience in the prevalence of various clinical manifestations of iron deficiency conditions and made an attempt to generalize their etiological data. The article deals with the issues of latent iron deficiency, and describes the scenarios for the development of absolute and functional deficiencies in iron deficiency anemia. Particular attention is paid to the search for scientific sources reporting on the influence of psychological factors on the occurrence and development of iron deficiency conditions.</abstract><kwd-group xml:lang="en"><kwd>iron deficiency</kwd><kwd>anemia</kwd><kwd>women</kwd><kwd>ferritin</kwd><kwd>total blood protein</kwd><kwd>stress</kwd><kwd>anxiety</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>железодефицитная анемия</kwd><kwd>женщины</kwd><kwd>ферритин</kwd><kwd>общий белок</kwd><kwd>стресс</kwd><kwd>тревожность</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Железодефицитная анемия: клинические рекомендации. М.; 2020.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>De Falco L., Silvestri L., Kannengiesser C. et al. Functional and clinical impact of novel TMPRSS6 variants in iron-refractory iron-deficiency anemia patients and genotype-phenotype studies // Hum. Mutat. 2014. Vol. 35. P. 1321-1329.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Струтынский А. В. Диагностика и лечение железодефицитных анемий // Русский медицинский журнал. 2014. № 11. С. 839-843.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Camaschella C. Iron-deficiency anemia // N. Engl. J. Med. 2015. Vol. 372. P. 1832-1843.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Fraser I. S., Mansour D., Breymann C. et al. Prevalence of heavy menstrual bleeding and experiences of affected women in a European patient survey // Int. J. Gynaecol. Obstet. 2015. Vol. 128. P. 196-200.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Kassebaum N. J., Jasrasaria R., Naghavi M. et al. A systematic analysis of global anemia burden from 1990 to 2010 // Blood. 2014. Vol. 123. P. 615-624.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Camaschella C. New insights into iron deficiency and iron deficiency anemia // Blood Rev. 2017. Vol. 31. P. 225-233.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Cappellini M. D., Musallam K. M., Taher A. T. Iron deficiency anaemia revisited //j.Intern. Med. 2019. Vol. 287, N 2. P. 153-170. doi: 0.1111/joim.13004.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Lopez A., Cacoub P., Macdougall I. C., Peyrin-Biroulet L. Iron deficiency anaemia // Lancet. 2016. Vol. 387, N 10021. P. 907-916.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Heidelbaugh J. J. Proton pump inhibitors and risk of vitamin and mineral deficiency: evidence and clinical implications // Ther. Adv. Drug Saf. 2013. Vol. 4. P. 125-133.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Gasche C., Lomer M. C., Cavill I., Weiss G. Iron, anaemia, and inflammatory bowel diseases // Gut. 2004. Vol. 53. P. 1190-1197.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Kulnigg-Dabsch S., Resch M., Oberhuber G. et al. Iron deficiency workup reveals high incidence of autoimmune gastritis with parietal cell antibody as reliable screening test // Semin. Hematol. 2018. Vol. 55. P. 256-261.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Hershko C., Camaschella C. How I treat unexplained refractory iron deficiency anemia // Blood. 2014. Vol. 123. P. 326-333.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Enns R. A., Hookey L., Armstrong D. et al. Clinical practice guidelines for the use of video capsule endoscopy // Gastroenterology. 2017. Vol. 152. P. 497-514. doi: 10.1053/j.gastro.2016.12.032.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Kiss J. E., Vassallo R. R. How do we manage iron deficiency after blood donation? // Br. J. Haematol. 2018. Vol. 181. P. 590-603.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Cable R. G., Glynn S. A., Kiss J. E. et al. Iron deficiency in blood donors: analysis of enrollment data from the REDS-II Donor Iron Status Evaluation (RISE) study // Transfusion. 2011. Vol. 51. P. 511-522.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Cohen-Solal A., Damy T., Terbah M. et al. High prevalence of iron deficiency in patients with acute decompensated heart failure // Eur. J. Heart Fail. 2014. Vol. 16. P. 984-991.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Jankowska E. A., Rozentryt P., Witkowska A. et al. Iron deficiency: an ominous sign in patients with systolic chronic heart failure // Eur. Heart J. 2010. Vol. 31. P. 1872-1880.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Klip I. T., Comin-Colet J., Voors A. A. et al. Iron deficiency in chronic heart failure: an international pooled analysis // Am. Heart J. 2013. Vol. 165. P. 575-582.e3.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Oustamanolakis P., Koutroubakis I. E., Messaritakis I. et al. Measurement of reticulocyte and red blood cell indices in the evaluation of anemia in inflammatory bowel disease //j. Crohns Colitis. 2011. Vol. 5, N 4. P. 295-300.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Антипов В. А., Трошин А. Н. Вопросы нормативно-правового регулирования в ветеринарной медицине. СПб.; 2015. P. 95-97.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>McMurray J. J., Adamopoulos S., Anker S. D. et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC // Eur. Heart J. 2012. Vol. 33, N 14. P. 1787-1847.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Pynaert I., Delanghe J., Temmerman M., De Henauw S. Iron intake in relation to diet and iron status of young adult women // Ann. Nutr. Metab. 2007. Vol. 51. P. 172-181.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Quintas M. E., Requejo A. M., Ortega R. M. et al. The female Spanish population: a group at risk of nutritional iron deficiency // Int. J. Food Sci. Nutr. 1997. Vol. 48. P. 271-279.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Thomas D. W., Hinchliffe R. F., Briggs C. et al. Guideline for the laboratory diagnosis of functional iron deficiency // Br. J. Haematol. 2013. Vol. 161. P. 639-648.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Bermejo F., Garc a-L pez S. A guide to diagnosis of iron deficiency and iron deficiency anemia in digestive diseases // World J. Gastroenterol. 2009. Vol. 15. P. 4638. doi: 10.3748/wjg.15.4638.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Cook J. D., Baynes R. D., Skikne B. S. Iron deficiency and the measurement of iron status // Nutr. Res. Rev. 1992. Vol. 5. P. 198-202. doi: 10.1079/NRR19920014.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Guyatt G. H., Oxman A. D., Ali M. et al. Laboratory diagnosis of iron-deficiency anemia //j. Gen.Intern. Med. 1992. Vol. 7. P. 145-153. doi: 10.1007/BF02598003.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Goodnough L. T., Nemeth E., Ganz T. Detection, evaluation, and management of iron-restricted erythropoiesis // Blood. 2010. Vol. 116. P. 4754-4761.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Thomas D. W., Hinchliffe R. F., Briggs C. et al. Guideline for the laboratory diagnosis of functional iron deficiency // Br. J. Haematol. 2013. Vol. 161. P. 639-648.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Finberg K. E., Heeney M. M., Campagna D. R. et al. Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA) // Nat. Genet. 2008. Vol. 40. P. 569-571.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Lopez A., Cacoub P., Macdougall I. C., Peyrin-Biroulet L. Iron deficiency anaemia // Lancet. 2016. Vol. 387. P. 907-916.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Hershko C., Camaschella C. How I treat unexplained refractory iron deficiency anemia // Blood. 2014. Vol. 123. P. 326-333.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Guyatt G. H., Oxman A. D., Ali M. et al. Laboratory diagnosis of iron-deficiency anemia //j. Gen.Intern. Med. 1992. Vol. 7. P. 145-153. doi: 10.1007/BF02598003.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Hallberg L. Results of surveys to assess iron status in Europe // Nutr. Rev. 1995. Vol. 53. P. 314-322.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Heidelbaugh J. J. Proton pump inhibitors and risk of vitamin and mineral deficiency: evidence and clinical implications // Ther. Adv. Drug. Saf. 2013. Vol. 4. P. 125-133.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Achebe M. M., Gafter-Gvili A. How I treat anemia in pregnancy: iron, cobalamin, and folate // Blood. 2017. Vol. 129. P. 940-949.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Assessing the Iron Status of Populations. 2nd ed. Geneva; 2007.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Baker R. D., Greer F. R. Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0-3 years of age) // Pediatrics. 2010. Vol. 126. P. 1040-1050. doi: 10.1542/peds.2010-2576.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Silber M. H., Ehrenberg B. L., Allen R. P. An algorithm for the management of restless legs syndrome // Mayo Clinic Proc. 2004. Vol. 79, N 7. Р. 916-922.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Patrick L. R. Restless legs syndrome: pathophysiology and the role of iron and folate // Altern. Med. Rev. 2007. Vol. 12, N 2. P. 101-112.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Edinger J. D., Sampson W. S. A primary care “friendly” cognitive behavioral insomnia therapy // Sleep. 2003. Vol. 26, N 2. Р. 177-182.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Hertenstein E., Johann A., Baglioni C. et al. Treatment of insomnia - a preventive strategy for cardiovascular and mental disorders // Mental Health &amp; Prevention. 2016. Vol. 4, N 2, P. 96-103. doi: 10.1016/j.mhp.2016.02.005.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Costa M. B., Stein A. T. Pharmacological and psychosocial interventions for night eating syndrome in adults // Cochrane Database of Systematic Reviews. 2015. N 4. P. 1-27.</mixed-citation></ref></ref-list></back></article>
