REMEDIUM

Introduction. About a quarter of the world's population suffers from helminthic invasion. Praziquantel is a drug for the treatment of helminthiasis caused by cestodes and trematodes. The development of generic drugs for the fight against helminthiasis in Russia seems to be relevant.The aim of the study was to compare the pharmacokinetics profiles of generic Praziquantel and Biltricid® (reference drug), to assess their safety during their bioequivalence study.Materials and methods. An open, randomized, crossover, four-period, replicative design study was conducted on 32 male healthy volunteers.Results. Similar pharmacokinetic profiles of praziquantel were found when volunteers took Praziquantel and Biltricid®. According to the analysis of variance, the main factors that make a significant contribution to the observed variability of the data were interindividual differences in volunteers and the sequence of taking drugs. 90% CI of the ratios of AUC0-t, AUC0-∞, and Cmax of the tested drug to the reference one were in the range of 80-125%. Praziquantel preparations have been found to have a satisfactory safety profile.

The article presents a review of the literature of theoretical and practice-oriented publications on the organization of nutrition and nutritional support for patients of the intensive care unit. The main conditions of the organization of nutritive nutrition, the conditions of its effectiveness, nutrition factors contributing to the recovery of patients are highlighted. The features of patients in the intensive care unit that determine the need for nutritional support are determined.

This article analyzes the ratio of expenditures on drug provision for patients with rare life-threatening diseases to the total amount of expenses of the constituent entities of the Russian Federation on preferential drug provision. The share of expenditures on rare life-threatening diseases in the structure of regional expenditures on drug provision in 2019 and 2020 is presented. The dynamics of the budget for rare life-threatening diseases in monetary terms and the dynamics of regional spending on drug provision were also analyzed in comparison with 2019 and 2020. Finally, results were obtained regarding the share of expenditures on rare life-threatening diseases in the structure of regional expenditures on drug provision in the planned year 2021. Consistent federalization of drug provision for patients with certain rare life-threatening diseases, first of all, has transferred the drug provision of pediatric patients with such nosologies to the federal level. In order to further harmonize the system and equalize the availability of drug provision for adults and children with rare life-threatening diseases, it is necessary to think about the federalization of the most “costly” diseases for regions with a predominantly adult cohort of patients.

The purpose of the study: to analyze the effect of education on the attitude to compliance with the doctor's recommendations by surgical patients.Materials and methods. Information was obtained through an anonymous questionnaire of 401 inpatient patients. Two comparison groups were formed: 221 people had higher or unfinished higher education, and 180 people had secondary or secondary-special education. Among the patients studied, there were no those who had a professional medical education. Three age groups stood out: 23-44 years old, 45-59 years old and 60 years old and older. Since higher education can only be obtained by the age of 22-23 and the use of younger age groups in this case is incorrect.Results. Regardless of gender, the general trend was a decrease in the specific gravity of those who comply with doctor's appointments with increasing age. Among men in all age groups, patients with a high level of education performed prescriptions and recommendations of the doctor more often, than low-education patients, and among women, high-education patients performed physician prescriptions and recommendations more frequently, than patients with low levels of education only in the young and middle age groups, and in the older age group, the proportion of those who always fulfill the prescriptions of a doctor in full among women with a high level of education is reduced by increasing the proportion of those performing the prescriptions of a doctor only if he considers it necessary. The same patterns, in general, are observed in relation to the implementation of the principles of a healthy lifestyle. But in men, the influence of education level is manifested after 45 years and in the middle and older age groups the number of those who perform them only if they consider it necessary increases. In women, the influence of educational level on the frequency of implementation of the principles of a healthy lifestyle is more pronounced in all age groups. Also, like men, with increasing age, the proportion of women who believe that it is necessary to fulfill doctor's appointments only if they themselves consider it necessary.

The effectiveness of measures taken to stabilize and reduce the incidence of COVID-19 was assessed against the background of studying the main resource indicators of healthcare and interaction with other sectors of the economy.The main results of the study made it possible to expand the understanding of the concept of biological safety, which is interpreted by Federal Law as "the state of protection of the population and the environment from the effects of hazardous biological factors, in which an acceptable level of biological risk is provided," and the applied set of control measures can be assessed as typical for such global biological calls. The results obtained make it possible to believe that, in general, public administration in the field of public health is significantly focused on the localization of risks, which fully corresponds to the strategic objectives and goals of the country.

The official declaration by the WHO of a global pandemic of COVID-19 in 2020 led to various restrictive measures around the world in order to prevent the rapid spread of the virus. In many countries, it was decided to close educational institutions (schools, lyceums, colleges, universities) and switch to distance learning, which contributed to the deviation from the established lifestyle of students, including eating habits and, consequently, to a possible change in their weights. It has been proven that a complete, balanced diet and systematic exercise can strengthen the human body in the fight against adverse factors, including infectious ones. However, a sedentary lifestyle, anxiety, stress caused by social isolation lead to lifestyle changes, in particular to overeating.The article presents information about the characteristics of nutrition, the level of physical activity, anxiety and stress, taking into account the cultural, ethnic and gender characteristics of student youth from different countries in the context of the COVID-19 pandemic.

The article deals with the problems of formation of digital competencies in healthcare and medicine specialists. The main vectors of professional training of doctors are defined, the review of foreign experience in approaches to the organization of the system of training of medical workers in the field of medical informatics is carried out.

The authors present a triptych of articles revealing various aspects of Kremlin medicine, a system of Soviet healthcare designed exclusively for the political elites of the USSR and its associated countries and communist parties, as well as for the scientific and cultural elite. The second post deals with the composition of patients. Their own lists or "nomenclatures" institutionalized the political and cultural elites, as well as the circle of political friends of the USSR. The authors reveal the mechanism of including and excluding candidates from the circle of the chosen ones, who were guaranteed a decent old age and longevity with all the power of modern medicine. At the same time it is shown how the participation of Kremlin medics in big politics, their wide possibilities not only to get rid of illnesses, but also to decide the fates of patients undermined the trust of contemporaries to the Kremlin medicine.

The article analyzes the evolution of terms denoting penicillin produced in the USSR in the 1940s, as well as the motives that determined their transformation. It is shown that in the second half of the 1940s, the original names, which directly indicated the producer and the institution producing the drug, were replaced by the term “Soviet penicillin”, devoid of specifics, but corresponding to the political moment. Its introduction into circulation made it possible not to advertise the new strains that were tested and put into production, which did not always come to the USSR legally. The introduction of a new politically correct term and the upholding of domestic priority in the study of antibiotics joined the general course of ideological work in the conditions of the Cold War.