REMEDIUM

Introduction. In the Russian Federation, a trend towards an increase in diseases of the female reproductive system is recorded (38% is the proportion of patients with this pathology who have been under dispensary observation for at least 5 years). Over the years, new results from randomized, controlled clinical trials in women with cancer have been accumulating. A serious challenge for scientists is the problem of overcoming the phenomenon of «escape» of the tumor during systemic drug therapy. In this regard, the rationale for choosing the most effective treatment options is being carried out, by determining predictive and prognostic biomarkers. From March 18 to 21, 2022, the Women's Cancer Annual Congress (USA), organized by the Gynecological Oncology Society, was held, where, among others, important results of clinical trials of ovarian cancer therapy were announced.Target. Summarizing the results of clinical trials discussed on the digital platform of the Dutch educational platform for healthcare professionals in connection with their presentation at the Congress of the Oncogynecological Society on Cancer of the Female Reproductive System in March 2022.Materials and methods. The scientific study was based on the results of a search in the database of the Dutch educational platform for healthcare professionals, the PubMed / Medline database and the Google search engine. We analyzed the results published at the beginning of 2022.Results. Systematized and studied the results of new clinical developments on the drug therapy of patients with ovarian cancer, presented at the congress of the Oncogynecological Society. To date, breakthrough results of innovative clinical studies have been obtained in the world with the definition of effective approaches to the choice of individualized targeted, immuno- and chemotherapy for the treatment of patients with ovarian cancer: SOLO3, PRIME, SORAYA, iPOCC, ARTISTRY-1, etc.Discussion and conclusions. Taking into account the results of the conference, it seems clear that personalized technologies are a long-awaited and promising approach. Despite many challenges, these individualized treatment principles are slowly becoming the daily reality of oncological care for ovarian cancer patients.

Assortment of industrially manufactured solutions for parenteral use a pediatric multidisciplinary hospital - the Children's Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan (DRCH) being discussed in the article. The paper presents the distribution of drugs for parenteral administration by producing countries, anatomical-therapeutic-chemical (ATC) - classification of the assortment of injection solutions. ABC-analysis of the most expensive groups, assortment analysis according to the nomenclature of medicines were carried out. In 2021 the largest number of items used a multidisciplinary hospital was revealed among the group of drugs affecting blood and hematopoiesis, while the most financially costly group were drugs for the treatment of diseases of the musculoskeletal system. The greatest financial expenses fall on the dosage form of solutions for injections in ampoules. TOP-10 expensive medicines for parenteral use have been determined. It has been established that the most purchased drugs for parenteral administration were the drugs from the group of antibiotics, plasma-substituting agents and solvents. Pediatric dosages of these drugs are not presented in the State Register of Medicines.

Mental health is an integral part and the most important component of human health. However, today half of the population of our country has signs of its violation, of which about 5% need professional psychiatric care. Mental disorders lead to a significant decrease in the quality of life, disability of the population, as well as prolonged and recurrent disability. In recent years, the COVID-19 pandemic has caused significant negative consequences for mental health. According to research data in 2020 every third resident of Russia complained of symptoms of depression. Fear, anxiety, depression associated with the introduction of restrictive measures and self-isolation have led to the emergence of chronic stress in the population, which is one of the harbingers of the development of mental disorders. In 2022, the deterioration of mental health is noted against the background of the current political situation in the world. Frequent manifestations of stress lead to various psychoemotional disorders (anxiety, increased irritability, neurosis, sleep disorders, etc.). To avoid these consequences, drugs of various pharmacological groups (sedatives, nootropic, adaptogens, antidepressants and others) are used in the complex therapy of anxiety disorders. Within the framework of the concept of responsible self-treatment, the therapy of these disorders is carried out with over-the-counter medications.

In 2020-2021, COVID-19 pandemic made a significant impact on the pharmaceutical market in developed countries as well as developing ones. Since 2019 the Russian pharmaceutical market has been demonstrating high growth rates in value terms with the main contribution made by the public (reimbursement) sector of the market.The goal was to study the main trends in the medicines consumption in the public sector of the Russian pharmaceutical market.Materials and methods. The analysis was based on IQVIA data, including preferential medicines supply (MS) for outpatients, MS for hospitalized patients, centralized federal MS programs, and other MS. The IQVIA data did not consider the use of COVID-19 vaccines.Results. In 2019-2021, the average annual growth rate of the public sector was 125.4% in value terms, which was determined by shifts in the consumption structure in favor of more expensive drugs. The main contribution to the positive dynamics was made by the hospital segment, share of which increased over the three years by 17 percentage points up to 45%. The dynamics of preferential MS programs lagged the general growth rates. The main impact on the market had made the following pharmacotherapeutic groups (according to ATC classification): anticancer drugs (groups L01, L02), immunosuppressants (L04), antivirals (J05), antithrombotics (B01), drugs for the treatment of spinal muscular atrophy (M09). The contribution of domestic-made production to the growth in value terms consisted of 38% over three years. Its share in the consumption structure increased by 2.4 percentage points up to 35.4%.Discussion. The prerequisites for the high dynamics of the public sector in 2019 was a significant increase in government healthcare spending, including the expansion of existing MS programs. In 2020-2021, the COVID-19 epidemic had the main impact on the volume and structure of medicines consumption, as well as an increase in funding and the launch of new MS programs. During the COVID-19 epidemic, the consumption of domestic-made drugs, including new original ones, has increased.Conclusion. As in other countries, in the coming years, the factor of controlling COVID-19 epidemic will no longer make a key impact on the dynamics of the Russian pharmaceutical market, while the expansion of reimbursed MS programs will especially being actual to the expected decline in household incomes.

Introduction. One of the main factors determining the interest in the study of scientific issues and their development is the availability of publications on the relevant topic, and consequently, the existence of a publication landscape that can be characterized by various scientometric indicators. At the same time, a bibliographic analysis of domestic and foreign sources showed the existence of an information gap in the bibliometric study of the subject area «Health Management» itself. Therefore, it is of particular interest to conduct a general scientometric analytical study on the study of the publication landscape formed by scientific works related to the consideration of theoretical and practical aspects and the analysis of the main thematic clusters from the field of health management.Materials and methods. The study was conducted using an analytical platform (an online tool) SciVal, the data source for which is the international scientific citation database Scopus. The following indicators were selected as scientometric indicators: the total number of publications, the number of publications in the TOP 25% of the most cited, the number of publications in scientific publications 1-2 quartiles, the number of publications in international and national collaborations (cooperation), average citation, citation level. When considering thematic (research) clusters, the main indicators characterizing them are: number, English and Russian names, number of publications, citation level and prominence percentile.Results and discussion. Monitoring and analysis of scientometric indicators can serve as one of the tools for determining the effectiveness of research activities of a particular author, structural unit, organization and the country as a whole. However, such work is impossible without taking into account global trends in the development of medical science and the analysis of global thematic (research) clusters, the identification of which and the identification of priority areas of scientific research in the world, the Russian Federation and Moscow is crucial at the stages of planning scientific activities.Conclusion. The subject area «Health policy» («Health management») is characterized by steady growth and positive dynamics of changes in scientometric indicators reflecting the publication activity of scientists and researchers at the global, national and regional levels, i.e. in the world, the Russian Federation and Moscow.

Introduction. After COVID-19, survivors often report post-COVID syndrome (PCS), which presents with a wide range of new, recurring, or ongoing symptoms lasting weeks or months after exposure to SARS-CoV-2. PCS is a poorly understood condition due to chronic, mild inflammation theorized as a pathophysiological mechanism.Aim. Our goal is to search for biomarkers for accurate identification of PCD, its treatment and prevention in men of different ages who recovered from COVID-19 as a result of SARS-CoV-2 Delta and Omicron.Materials and methods. The study is based on data from a population cohort study of the health status of Muscovites aged 18 years and over during in-depth medical examinations. Participants had a history of a positive SARS-CoV-2 test result or a diagnosis of COVID-19 that was at least 60 days after recovery. He completed a list of laboratory tests: complete blood count, ESR (in 2022), D-dimer and 7 biochemical biomarkers. Men were divided into age groups: 18-39, 40-59, 60+ years old. We recorded the values of the norm, above the norm, critically above the norm, below the norm and critically below the norm.Results. Statistically significant laboratory parameters with abnormal values were determined: leukocytes, lymphocytes, monocytes, eosinophils, hemoglobin, platelets, D-dimer, cholesterol, LDL, CRP, ALT, AST, LDH, creatinine (p < 0.01%).Discussion. An abbreviated working list of laboratory biomarkers for the primary sorter of PKC in men of different age groups was developed: “18-39 years old” - cholesterol, LDL, ALT, AST and CRP (p < 1%); «40-59 years old» - cholesterol, LDL, D-dimer, CRP, ALT, AST and ESR (p < 1%); «60+ years old» - D-dimer, cholesterol, LDL, ESR, CRP, creatinine, AST, Їplatelets and leukocytes (p < 1%).Conclusion. Monitoring the values of the established list of biomarkers is effective for the initial adequate sorting of men after COVID-19 who need dispensary observation and rehabilitation.

Introduction. The authors analyze the ethical issues associated with the vaccination of medical school employees against COVID-19.Purpose. The purpose of this article is to determine the ethical aspects of the corporate program for the prevention of COVID-19 among employees of a medical university.Materials and methods. The following research methods were used in the work: study and analysis of special literature, synthesis, modeling, comparison, generalization, observation, system analysis and theoretical knowledge.Results. It is concluded that the violation of the basic principles of voluntariness and awareness, as well as the lack of proper control of the quality, efficacy and safety of vaccines reduce the confidence of medical school workers and society as a whole in vaccination.Discussion. The teaching staff, medical teachers are highly educated intellectual specialists who are well versed in their scientific and related fields, deeply analyzing various aspects of clinical vaccine research. The departmental staff of a medical university is able to critically assess the positions of colleagues who develop and promote vaccines, hush up or ignore any facts.Conclusion. Therefore, educational and explanatory activities with this category of workers should involve a constructive scientific dialogue without sweeping accusations and labeling in the style of a talk show. The article contains a number of ethical recommendations that must be kept in mind when vaccinating.

This article discusses the aspects of using the Internet space for communication of medical and healthcare professionals, primarily through blogging. The factors influencing the increase in the number of blogs are given, the most popular topics for blogging about health are listed. The influence of blogs about medicine on the healthcare industry as a whole is analyzed. The objectives of creating medical blogs and their key features are considered. The advantages of maintaining such blogs for authors and readers are given.

The article is devoted to the study of worldview ideas about syphilis among the Mongolian peoples and traditional methods of folk and Tibetan medicine in the treatment of venereal diseases.