REMEDIUMREMEDIUM1561-59362658-3534Joint-Stock Company Chicot146810.32687/1561-5936-2022-26-4-292-297Review articleReproductive technologies in solving the problems of infertility of the population (Part II)TliashinovaI. A.-SadykovaR. N.-MingazovaE. N.elmira_mingazova@mail.ruN. A. Semashko National Research Institute of Public HealthI. M. Sechenov First Moscow State Medical University (Sechenov University)Pirogov Russian National Research Medical UniversityKazan State Medical University1512202226429229706122022Copyright © 2022,2022Human reproduction issues remain not only relevant, but also increasing in importance among the population of different countries. The reason is that the incidence of infertility does not decrease, the age of marriage increases and, accordingly, the age at which the first birth occurs increases. In connection with the above, the assisted reproductive technologies introduced today are not only a means of treating infertility, but also a method to meet these requirements. A special place in research is occupied by the problem of the most important hormone that triggers the maturation of oocytes - human chorionic gonadotropin. Studies have shown that mast cells, induced from membrane cells, affect embryonic development and are involved in the pathology of female infertility. Mast cells play a role in the maintenance of pregnancy and cancer metastasis, which is of interest for further research in the field of normal and pathological cell development.As a result, it was revealed which modern approaches influence the solution of the problem of reproductive disorders, the risk factors for reproductive health were assessed, and methods were proposed to reduce the influence of these factors.correction of reproductive functionshuman chorionic gonadotropinmast cellsinfertilityкоррекция репродуктивных функцийхорионический гонадотропин человекатучные клеткибесплодие1.Nwabuobi C., Arlier S., Schatz F. et al. hCG: biological functions and clinical applications // Int. J. Mol. Sci. 2017. Vol. 18, N 10. P. 2037. DOI: 10.3390/ijms181020372.Gridelet V., Perrier d'Hauterive S., Polese B. et al. Human chorionic gonadotrophin: new pleiotropic functions for an «old» hormone during pregnancy // Front Immunol. 2020. Vol. 11. P. 343. 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DOI: 10.1007/s00404-019-05388-27.Brady P. C., Farland L. V., Racowsky C., Ginsburg E. S. Hyperglycosylated human chorionic gonadotropin as a predictor of ongoing pregnancy // Am. J. Obstet. Gynecol. 2020. Vol. 222, N 1. P. 68.e1-68.e12. DOI: 10.1016/j.ajog.2019.08.0048.Segal T. R., Amini P., Wang J. et al. Superovulation with human chorionic gonadotropin (hCG) trigger and gonadotropin releasing hormone agonist (GnRHa) trigger differentially alter essential angiogenic factors in the endometrium in a mouse ART model // Biol. Reprod. 2020. Vol. 102, N 5. P. 1122-1133. DOI: 10.1093/biolre/ioaa0149.Glavaski M., Banovic P., Lalosevic D. Number and distribution of mast cells in reproductive systems of gravid and non-gravid female mice // Serbian Journal of Experimental and Clinical Research. 2019. DOI: 10.2478/sjecr-2019-004710.Bian G., Gu Y., Xu C. et al. Early development and functional properties of tryptase/chymase double-positive mast cells from human pluripotent stem cells //j. Mol. 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