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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher">REMEDIUM</journal-id><journal-title-group><journal-title>REMEDIUM</journal-title></journal-title-group><issn publication-format="print">1561-5936</issn><issn publication-format="electronic">2658-3534</issn><publisher><publisher-name>Joint-Stock Company Chicot</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1470</article-id><article-id pub-id-type="doi">10.32687/1561-5936-2022-26-4-303-307</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Quality of life in patients with novel coronavirus infection: association with disease severity and change depending on rehabilitation regimens after inpatient treatment</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Romanov</surname><given-names>A. O.</given-names></name><bio></bio><email>alexseu23ru@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Arkhangelskaya</surname><given-names>A. N.</given-names></name><bio></bio><email>-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Sharipova</surname><given-names>M. M.</given-names></name><bio></bio><email>-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Gurevich</surname><given-names>K. G.</given-names></name><bio></bio><email>-</email><xref ref-type="aff" rid="aff-1"/><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff id="aff-1">A. I. Yevdokimov Moscow State University of Medicine and Dentistry</aff><aff id="aff-2">Research Institute for Healthcare Organization and Medical Management of Moscow Healthcare Department</aff><pub-date date-type="epub" iso-8601-date="2022-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2022</year></pub-date><volume>26</volume><issue>4</issue><fpage>303</fpage><lpage>307</lpage><history><pub-date date-type="received" iso-8601-date="2022-12-06"><day>06</day><month>12</month><year>2022</year></pub-date></history><permissions><copyright-statement>Copyright © 2022,</copyright-statement><copyright-year>2022</copyright-year></permissions><abstract>Objective. Imbalance of vitamin and mineral substances is considered as one of the leading functional conditions in patients with post-COVID syndrome.Materials and Methods. Тotal of 195 consecutively recruited patients were examined. The average age of the surveyed was 54 (12.1) years. After discharge from the hospital, patients were randomly recommended four rehabilitation regimens: Group A - standard rehabilitation, mainly including anticoagulant therapy (n = 47); Group B - where, in addition to standard methods, vitamin preparations were administered (n = 49); Group C - where, in addition to standard methods, mineral preparations were administered (n = 48); Group D - where, in addition to standard methods, vitamins and mineral preparations were administered (n = 51). The quality of life was assessed using the scales of the SF-36 questionnaire.Results. Patients with severe COVID-19 had a lower quality of life on admission and discharge from the hospital than those with moderate disease. Rehabilitation activities within 6 months after an acute coronavirus infection, the quality of life was increased by 10-20%. The most pronounced result was observed in patients of group D, who used trace elements in combination with vitamins.Conclusion. Intake of vitamin-mineral complexes into rehabilitation regimens improves the quality of life of patients with post-COVID syndrome.</abstract><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>COVID-19</kwd><kwd>rehabilitation</kwd><kwd>quality of life</kwd><kwd>vitamins</kwd><kwd>minerals</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>реабилитация</kwd><kwd>качество жизни</kwd><kwd>витамины</kwd><kwd>минералы</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Nedjimi B. Can trace element supplementations (Cu, Se, and Zn) enhance human immunity against COVID-19 and its new variants? // Beni. Suef. Univ. J. Basic Appl. Sci. 2021. Vol. 10, N 1. P. 33. DOI: 10.1186/s43088-021-00123-w</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Gasmi A., Peana M., Pivina L. et al.Interrelations between COVID-19 and other disorders // Clin. Immunol. 2021. Vol. 224. P. 108651. DOI: 10.1016/j.clim.2020.108651</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Muñoz-Corona C., Gutiérrez-Canales L. G., Ortiz-Ledesma C. et al. Quality of life and persistence of COVID-19 symptoms 90 days after hospital discharge //j.Int. Med. Res. 2022. Vol. 50, N 7. P. 3000605221110492. DOI: 10.1177/03000605221110492</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Mammi P., Ranza E., Rampello A. et al. Post COVID-19 ongoing symptoms and health related quality of life: does rehabilitation matter? Preliminary evidence // Am. J. Phys. Med. Rehabil. 2022. DOI: 10.1097/PHM.0000000000002089</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>de Blasio F., Scalfi L., Castellucci B. et al. Poor nutritional status and dynapenia are highly prevalent in post-acute COVID-19 // Front. Nutr. 2022. Vol. 9. P. 888485. DOI: 10.3389/fnut.2022.888485</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Alexander J., Tinkov A., Strand T. A. et al. Early nutritional interventions with zinc, selenium and vitamin d for raising anti-viral resistance against progressive COVID-19 // Nutrients. 2020. Vol. 12, N 8. P. 2358. DOI: 10.3390/nu12082358</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>James P. T., Ali Z., Armitage A. E. et al. The role of nutrition in COVID-19 susceptibility and severity of disease: a systematic review //j. Nutr. 2021. Vol. 151, N 7. P. 1854-1878. DOI: 10.1093/jn/nxab059</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Ayer C., Celep A. G. S. Assessment of dietary habits and use of nutritional supplements in COVID-19: a cross-sectional study // PharmaNutrition. 2022. Vol. 22. P. 100309. DOI: 10.1016/j.phanu.2022.100309</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Islam M. T., Quispe C., Martorell M. et al. Dietary supplements, vitamins and minerals as potential interventions against viruses: perspectives for COVID-19 // Int. J. Vitam. Nutr. Res. 2022. Vol. 92, N 1. P. 49-66. DOI: 10.1024/0300-9831/a000694</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Galmés S., Serra F., Palou A. Current state of evidence: influence of nutritional and nutrigenetic factors on immunity in the COVID-19 pandemic framework // Nutrients. 2020. Vol. 12, N 9. P. 2738. DOI: 10.3390/nu12092738</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Junaid K., Ejaz H., Abdalla A. E. et al. Effective immune functions of micronutrients against SARS-CoV-2 // Nutrients. 2020. Vol. 12, N 10. P. 2992. DOI: 10.3390/nu12102992</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Pecora F., Persico F., Argentiero A. et al. The role of micronutrients in support of the immune response against viral infections // Nutrients. 2020. Vol. 12, N 10. P. 3198. DOI: 10.3390/nu12103198</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Gasmi A., Tippairote T., Mujawdiya P. K. et al. Micronutrients as immunomodulatory tools for COVID-19 management // Clin. Immunol. 2020. Vol. 220. P. 108545. DOI: 10.1016/j.clim.2020.108545</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Calder P. C., Carr A. C., Gombart A. F., Eggersdorfer M. Optimal nutritional status for a well-functioning immune system is an important factor to protect against viral infections // Nutrients. 2020. Vol. 12, N 4. P. 1181. DOI: 10.3390/nu12041181</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Schuetz P., Gregoriano C., Keller U. Supplementation of the population during the COVID-19 pandemic with vitamins and micronutrients - how much evidence is needed? // Swiss Med. Wkly. 2021. Vol. 151. P. w20522. DOI: 10.4414/smw.2021.20522</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Shakoor H., Feehan J., Al Dhaheri A. S. et al. Immune-boosting role of vitamins D, C, E, zinc, selenium and omega-3 fatty acids: could they help against COVID-19? // Maturitas. 2021. Vol. 143. P. 1-9. DOI: 10.1016/j.maturitas.2020.08.003</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Sousa-Catita D., Godinho C., Mascarenhas P. et al. The effects of an intensive rehabilitation program on the nutritional and functional status of post-COVID-19 pneumonia patients // Nutrients. 2022. Vol. 14, N 12. P. 2501. DOI: 10.3390/nu14122501</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Czapla M., Juárez-Vela R., Gea-Caballero V. et al. The association between nutritional status and in-hospital mortality of COVID-19 in critically-ill patients in the ICU // Nutrients. 2021. Vol. 13, N 10. P. 3302. DOI: 10.3390/nu13103302</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Ghanem J., Passadori A., Severac F. et al. Effects of rehabilitation on long-covid-19 patient's autonomy, symptoms and nutritional observance // Nutrients. 2022. Vol. 14, N 15. P. 3027. DOI: 10.3390/nu14153027</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Harenwall S., Heywood-Everett S., Henderson R. et al. Post-COVID-19 syndrome: improvements in health-related quality of life following psychology-led interdisciplinary virtual rehabilitation //j. Prim. Care Commun. Health. 2021. Vol. 12. P. 21501319211067674. DOI: 10.1177/21501319211067674</mixed-citation></ref></ref-list></back></article>
