REMEDIUM

Как сообщила газета Global Times, китайские специалисты приступили к испытанию на людях первой вакцины против нового коронавируса. Она появилась на свет благодаря совместным усилиям китайской фармы и специалистов Академии военных медицинских наук Народноосвободительной армии Китая (НОАК). По информации издания, были использованы наработки по созданию вакцины против вируса Эбола.

The launch of a new drug to the pharmaceutical market should be well-thought-out and accompanied by intensive marketing promotion, which is the solution to a master problem - a strong start and subsequent growth of sales of a new drug. Today, this process (“launching”) is one of the key ones in the activities of each pharmaceutical company. The article discusses the most successful launches on the Russian pharmaceutical market following the results of 2019.

Редкие (орфанные) заболевания сопровождают немногочисленных пациентов всю их жизнь и, как правило, сильно ее осложняют, приводя к инвалидизации. Спасение таких больных практически не влияет на медицинскую статистику государства в целом, на среднюю продолжительность жизни в стране, не включено ни в какие целевые показатели федеральных программ. Но пациентское, медицинское и фармацевтическое сообщества объединились для спасения больных с редкими и очень дорогостоящими заболеваниями и уже многого добились. Специфика орфанных заболеваний такова, что без мощной финансовой поддержки государства ни лечения, ни даже производства специальных препаратов не будет. Сколько же готово платить государство за продление жизни орфанным пациентам?

The document legalizing the possibility of online drug retail was very lucky: there was an epidemic of coronavirus, self-isolation and boom in the development of remote services. All this made it impossible to further delay the adoption of the document. However, its «opponents» did everything possible to slow down the entry to the market for new players, including the giants of Internet retail. In fact, the process has been launched, but the main battle online is still ahead.

In the complex therapy of osteoarthritis (OA), both medicinal and non-medicinal methods are used. In Russia, they are guided by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). According to the recommendations of the American College of Rheumatology American College (ACR) in 2019, new approaches to OA therapy are proposed. Each of the methods of treatment, non-drug (changes in physical activity, body weight correction, kinesiotaping, wearing orthoses, acupuncture) and medication (non-steroidal anti-inflammatory drugs (NSAIDs), chondroprotectors), was evaluated. The appointment of chondroprotetcors (CP) - SYmptomatic Slow Acting Drugs for OsteoArthritis (SYSADOA) is being actively discussed. To chondroprotectors are preparations of chondroitin sulfate (CS) and glucosamine sulfate (GS). Proponents of CS and GS prescribing rely on numerous clinical studies that confirm the clinical efficacy and safety of CP. A randomized blind multicenter placebo-controlled clinical trial was conducted to study the efficacy and safety of Sustagard Artro for patients with parenteral knee OA (400 mg every other day for 6 weeks). An open randomized multicenter study to evaluate the effectiveness and safety of Chondrogard in various administration methods in patients with knee OA. The advantages were noted in the group of combined treatment (intravenous administration + subsequent intravenous administration). With any method of administration, the drug quickly and effectively reduced pain and stiffness, improved the functional state of the joints and with a high safety profile. There was a decrease in the need for NSAIDs.

Несмотря на достижения современной медицины, сахарный диабет (СД) остается одной из важнейших проблем здравоохранения в мире, в первую очередь ввиду своей высокой распространенности. По данным Международной федерации диабета (IDF), в 2019 г. число людей в возрасте 20-79 лет, страдающих СД, приблизилось к 463 млн [1]. В 2020 г. ситуацию усугубила эпидемия коронавируса - заболевания, наиболее опасного для людей с хроническими патологиями, в том числе с СД. В этих условиях особое значение приобретает грамотное управление СД, и прежде всего самоконтроль с помощью современных глюкометров.

Multiple clinical trials (CT) have confirmed the feasibility of using thioctic (alpha-lipoic acid) in the treatment of diabetic polyneuropathy (DPN) defined as specific peripheral nervous disfunction associated with diabetes mellitus (DM). Due to its high level of efficacy and safety, thioctic acid is included in the clinical guidelines for the treatment of DPN in some countries. This issue is also topical for the Russian medicine.

На сегодняшний день запор остается широко распространенным явлением. О природе запоров, особенностях профилактики и современном подходе к лечению мы решили узнать у Юрия КУЧЕРЯВОГО, доцента кафедры пропедевтики внутренних болезней и гастроэнтерологии Московского государственного медико-стоматологического университета, главного гастроэнтеролога Центральной дирекции здравоохранения «РЖД-Медицина».

Synthetic biology is a new interdisciplinary area of research applies the principles of engineering design in genetic and biomedical research. Progress in the development of tools used to modify natural biological systems (or used for creation of new ones) has allowed the development of traditional biomedicine and genomics. At the beginning of this review article, we look at the key achievements of synthetic biology over the past ten years. Despite the fact that the contribution of synthetic biology to fundamental research in the field of biology, medicine, ecology and other life sciences is undeniable, the potential risks for biological safety and security associated with the further development synthetic biology also require attention. This problem has become particularly relevant in recent years, as the technology becomes less expensive, more advanced and affordable. A brief assessment of the risks associated with the possible misuse or abuse of synthetic biology technologies is given from the point of view of danger to humanity and nature as a whole. To solve the problems arising due to the rapid progress of synthetic biology, technical, ethical and legal measures have been developed and planned.

The market research has been conducted using information on public procurement of osteosynthesis devices and the export-import transaction database of the official customs statistics. In the article, the term “osteosynthesis devices” is used to indicate the medical devices of this type. The purchase of such devices is most important to meet the needs of the public health system.The osteosynthesis implants consumption in value terms amounted to RUB 4.530 bil. in 2018. For the purposes of research, the regional groups of manufacturers of these products such as EU&US, Asian and Locals were identified.The Asian group manufacturers - 33% and Locals - 24% showed outperforming growth rates over the period from 2015 to 2018. The increase in the supplies of EU&US group manufacturers - 12% is below the market average figures. At the same time, a significant EU&US supplies gain was reported from 2017 to 2018. In 2018, a supplies gain for EU&US group accounted for more than 30%, as compared to 2017.According to MDpro, the total consumption of traumatology and orthopaedic devices amounted to about RUB 23.8 bil. at final prices in 2018. Of which, public procurement amounted to about RUB 22.1 bil., i.e. 92.7% of total consumption. Osteosynthesis implants make the greatest contribution to the private consumption. The share of Russian products in the domestic market of traumatology and orthopedic devices in2018 amounted to approximately 13% or about RUB 3.1 bil. at final prices.

Любая прорывная технология может стать спасением в одних руках и обернуться катастрофой в других. Особенно если она имеет огромный прикладной потенциал как молекулярная генетика. Ее стремительное развитие открывает перед человечеством не только качественно новый уровень решения его проблем, но и привносит новые, неизведанные угрозы. Широкому спектру этих угроз - от ионизирующего облучения до бактериологического оружия и ГМО-людей - был посвящен Международный симпозиум «Правовые проблемы обеспечения биологической безопасности в Российской Федерации», проведенный Московским государственным юридическим университетом им. О.Е. Кутафина и Российской медицинской академией непрерывного профессионального образования 22 мая в онлайн-формате.