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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher">REMEDIUM</journal-id><journal-title-group><journal-title>REMEDIUM</journal-title></journal-title-group><issn publication-format="print">1561-5936</issn><issn publication-format="electronic">2658-3534</issn><publisher><publisher-name>Joint-Stock Company Chicot</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">992</article-id><article-id pub-id-type="doi">10.21518/1561-5936-2020-9-46-50</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Bronchial asthma: fundamental changes in the new GINA guidelines(2019)</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Vodovozov</surname><given-names>Aleksey</given-names></name><bio></bio><email>noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff id="aff-1">Remedium</aff><pub-date date-type="epub" iso-8601-date="2020-12-09" publication-format="electronic"><day>09</day><month>12</month><year>2020</year></pub-date><issue>9</issue><fpage>46</fpage><lpage>50</lpage><history><pub-date date-type="received" iso-8601-date="2022-03-18"><day>18</day><month>03</month><year>2022</year></pub-date></history><permissions><copyright-statement>Copyright © 2020,</copyright-statement><copyright-year>2020</copyright-year></permissions><abstract>The new guidelines of the Global Initiative for Asthma (GINA) has inspired a heated discussion among experts. The next version was published in 2018, but its revision appeared as early as in 2019. This is primarily due to the revision of the attitude towards short-acting beta-2-agonists, however, the approaches have changed significantly at other stages of bronchial asthma treatment as well, especially at the early stages. The emphasis has been placed on low-dose inhaled corticosteroids, as they have accumulated an evidence base at an adequate quality level. In fact, the 2019 GINA proposals are reduced to discontinuation of the common clinical practice and switching to fundamentally different approaches to the management of bronchial asthma, especially its mild form.</abstract><kwd-group xml:lang="en"><kwd>bronchial asthma</kwd><kwd>inhaled corticosteroids</kwd><kwd>beta-2 agonists</kwd><kwd>clinical guidelines</kwd><kwd>GINA</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>бронхиальная астма</kwd><kwd>ингаляционные кортикостероиды</kwd><kwd>бета-2-агонисты</kwd><kwd>клиническое руководство</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Визель А.А. Бронхиальная астма: современные тенденции в лечении. Вестник современной клинической медицины. 2011;4(3):14-17.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Soriano J.B., Abajobir A.A., Abate K.H., Abera S.F., Agrawal A., Ahmed M.B. et al. 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