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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher">REMEDIUM</journal-id><journal-title-group><journal-title>REMEDIUM</journal-title></journal-title-group><issn publication-format="print">1561-5936</issn><issn publication-format="electronic">2658-3534</issn><publisher><publisher-name>Joint-Stock Company Chicot</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">968</article-id><article-id pub-id-type="doi">10.21518/1561-5936-2020-7-8-42-46</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>JAK inhibitors in rheumatoid arthritis: new opportunities and perspectives</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Shirokova</surname><given-names>Irina</given-names></name><bio></bio><email>noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff id="aff-1">Remedium</aff><pub-date date-type="epub" iso-8601-date="2020-12-07" publication-format="electronic"><day>07</day><month>12</month><year>2020</year></pub-date><issue>7-8</issue><fpage>42</fpage><lpage>46</lpage><history><pub-date date-type="received" iso-8601-date="2022-03-18"><day>18</day><month>03</month><year>2022</year></pub-date></history><permissions><copyright-statement>Copyright © 2020,</copyright-statement><copyright-year>2020</copyright-year></permissions><abstract>Rheumatoid arthritis (RA) is a pressing medical and social problem, on which researchers around the world are working. One of the solutions that could significantly improve the prognosis of patients’ treatment and their quality of life was discussed within the framework of the VI Rheumatology Summit held online on June 26-27 by the Association of Rheumatologists of Russia with the participation of leading Russian and foreign experts. The method is based on the use of upadacitinib, an innovative drug of JAK inhibitors class.</abstract><kwd-group xml:lang="en"><kwd>rheumatoid arthritis</kwd><kwd>JAK inhibitors</kwd><kwd>upadacitinib</kwd><kwd>clinical trials</kwd><kwd>remission</kwd><kwd>safety profile</kwd><kwd>cost-effectiveness</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>ревматоидный артрит</kwd><kwd>ингибиторы янус киназ</kwd><kwd>упадацитиниб</kwd><kwd>клинические исследования</kwd><kwd>ремиссия</kwd><kwd>профиль безопасности</kwd><kwd>экономическая эффективность</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Насонов Е.Л. 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