REMEDIUMREMEDIUM1561-59362658-3534Joint-Stock Company Chicot96610.21518/1561-5936-2020-7-8-29-32Original ArticleThe role of NSAIDs in the treatment of OA: new dataVodovozovAlexeynoemail@neicon.ruRemedium071220207-8293218032022Copyright © 2020,2020Modern therapy for osteoarthritis of any localization follows the principle on integrating patients’ concerns as much as possible, including thorough building of balance of benefits confirmed in strict accordance with the principles of evidence-based medicine, and potential harm due to unwanted side effects of the drugs used. In this case, NSAIDs gained a rightful place of drugs of choice, but the emphasis was placed on their systemic use, on oral forms for a long time. The new guidelines from the American College of Rheumatology (ACR) and the Osteoarthritis Research Society International (OARSI) are shifting the center of balance towards topical forms, focusing on current evidence of their effectiveness and safety. 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