<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher">REMEDIUM</journal-id><journal-title-group><journal-title>REMEDIUM</journal-title></journal-title-group><issn publication-format="print">1561-5936</issn><issn publication-format="electronic">2658-3534</issn><publisher><publisher-name>Joint-Stock Company Chicot</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">859</article-id><article-id pub-id-type="doi">10.21518/1561-5936-2021-2-62-68</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>A current approach to the treatment of ulcerative colitis: updated recommendations of the American Gastroenterological Association</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Vodovozov</surname><given-names>Alexey</given-names></name><bio></bio><email>-</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff id="aff-1">Remedium</aff><pub-date date-type="epub" iso-8601-date="2021-12-14" publication-format="electronic"><day>14</day><month>12</month><year>2021</year></pub-date><issue>2</issue><fpage>62</fpage><lpage>68</lpage><history><pub-date date-type="received" iso-8601-date="2022-03-17"><day>17</day><month>03</month><year>2022</year></pub-date></history><permissions><copyright-statement>Copyright © 2021,</copyright-statement><copyright-year>2021</copyright-year></permissions><abstract>Ulcerative colitis (UC) is a chronic inflammatory bowel disease that generally begins in young adulthood [1]. If left untreated, it can present with recurrent inflammations of the mucous membrane. Findings from population cohort studies show that UC follows a mild or moderate clinical course in most cases, the most active phase of the disease usually coincides in time with establishing diagnosis, followed by remission and exacerbation periods of varying length and intensity. Approximately 15% of patients may have an aggressive course of the disease, and 20% of such patients may require hospitalization due to the severity of the condition [2].</abstract><kwd-group xml:lang="en"><kwd>ulcerative colitis</kwd><kwd>moderate degree</kwd><kwd>severe degree</kwd><kwd>official recommendations of the American Gastroenterological Association</kwd><kwd>vedolizumab</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>язвенный колит</kwd><kwd>средняя степень</kwd><kwd>тяжелая степень</kwd><kwd>официальные рекомендации Американской гастроэнтерологической ассоциации</kwd><kwd>ведолизумаб</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Fumery M., Singh S., Dulai P.S., Gower-Rousseau C., PeyrinBiroulet L., Sandborn W.J. Natural History of Adult Ulcerative Colitis in Population-based Cohorts: A Systematic Review. Clin Gastroenterol Hepatol. 2018;16(3):343–356.e3. https://doi.org/10.1016/j.cgh.2017.06.016.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Narula N., Marshall J.K., Colombel J.F. et al. Systematic Review and Meta-Analysis: Infliximab or Cyclosporine as Rescue Therapy in Patients With Severe Ulcerative Colitis Refractory to Steroids. Am J Gastroenterol. 2016;111(4):477–491. https://doi.org/10.1038/ajg.2016.7.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Dassopoulos T., Cohen R.D., Scherl E.J., Schwartz R.M., Kosinski L., Regueiro M.D. Ulcerative Colitis Care Pathway. Gastroenterology. 2015;149(1):238–245. https://doi.org/10.1053/j.gastro.2015.05.036.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Feuerstein J.D., Isaacs K.L., Schneider Y., Siddique S.M., FalckYtter Y., Singh S; AGA Institute Clinical Guidelines Committee. AGA Clinical Practice Guidelines on the Management of Moderate to Severe Ulcerative Colitis. Gastroenterology. 2020;158(5):1450–1461. https://doi.org/10.1053/j.gastro.2020.01.006.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Schroeder K.W., Tremaine W.J., Ilstrup D.M. Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. N Engl J Med. 1987;317(26):1625–1629. https://doi.org/10.1056/NEJM198712243172603.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Truelove S.C., Witts L.J. Cortisone in ulcerative colitis; final report on a therapeutic trial. Br Med J. 1955;2(4947):1041–1048. https://doi.org/10.1136/bmj.2.4947.1041.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Singh S., Murad M.H., Fumery M., Dulai P.S., Sandborn W.J. Firstand second-line pharmacotherapies for patients with moderate to severely active ulcerative colitis: an updated network metaanalysis. Clin Gastroenterol Hepatol. 2020. https://doi.org/10.1016/j.cgh.2020.01.008.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Cipriani A., Higgins J.P., Geddes J.R., Salanti G. Conceptual and technical challenges in network meta-analysis. Ann Intern Med. 2013;159(2):130–137. https://doi.org/10.7326/0003-4819-159-2-201307160-00008.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Caprilli R., Carratù R., Babbini M. Double-blind comparison of the effectiveness of azathioprine and sulfasalazine in idiopathic proctocolitis. Preliminary report. Am J Dig Dis. 1975;20(2):115–120. https://doi.org/10.1007/BF01072336.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Jewell D.P., Truelove S.C. Azathioprine in ulcerative colitis: final report on controlled therapeutic trial. Br Med J. 1974;4(5945):627–630. https://doi.org/10.1136/bmj.4.5945.627.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Maté-Jiménez J., Hermida C., Cantero-Perona J., Moreno-Otero R. 6-mercaptopurine or methotrexate added to prednisone induces and maintains remission in steroid-dependent inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2000;12(11):1227–1233. https://doi.org/10.1097/00042737-200012110-00010.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Rosenberg J.L., Wall A.J., levin B., Binder H.J., Kirsner J.B. A controlled trial of azathioprine in the management of chronic ulcerative colitis. Gastroenterology. 1975;69(1):96–99. Available at: https://pubmed.ncbi.nlm.nih.gov/1097295.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Sood A., Midha V., Sood N., Kaushal V. Role of azathioprine in severe ulcerative colitis: one-year, placebo-controlled, randomized trial. Indian J Gastroenterol. 2000;19(1):14–16. Available at: https://pubmed.ncbi.nlm.nih.gov/10659481.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Ardizzone S., Maconi G., Russo A., Imbesi V., Colombo E., Bianchi Porro G. Randomised controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitis. Gut. 2006;55(1):47–53. https://doi.org/10.1136/gut.2005.068809.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Hawthorne A.B., logan R.F., Hawkey C.J. et al. Randomised controlled trial of azathioprine withdrawal in ulcerative colitis. BMJ. 1992;305(6844):20–22. https://doi.org/10.1136/bmj.305.6844.20.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Sood A., Kaushal V., Midha V., Bhatia K.L., Sood N., Malhotra V. The beneficial effect of azathioprine on maintenance of remission in severe ulcerative colitis. J Gastroenterol. 2002;37(4):270–274. https://doi.org/10.1007/s005350200034.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Sood A., Midha V., Sood N., Avasthi G. Azathioprine versus sulfasalazine in maintenance of remission in severe ulcerative colitis. Indian J Gastroenterol. 2003;22(3):79–81. Available at: https://pubmed.ncbi.nlm.nih.gov/12839376.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Herfarth H., Barnes E.L., Valentine J.F. et al. Methotrexate Is Not Superior to Placebo in Maintaining Steroid-Free Response or Remission in Ulcerative Colitis. Gastroenterology. 2018;155(4):1098–1108.e9. https://doi.org/10.1053/j.gastro.2018.06.046.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Oren R., Arber N., Odes S. et al. Methotrexate in chronic active ulcerative colitis: a double-blind, randomized, Israeli multicenter trial. Gastroenterology. 1996;110(5):1416–1421. https://doi.org/10.1053/gast.1996.v110.pm8613046.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Panaccione R., Ghosh S., Middleton S. et al. Combination therapy with infliximab and azathioprine is superior to monotherapy with either agent in ulcerative colitis. Gastroenterology. 2014;146(2):392–400.e3. https://doi.org/10.1053/j.gastro.2013.10.052.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Vermeire S., Gils A., Accossato P., lula S., Marren A. Immunogenicity of biologics in inflammatory bowel disease. Therap Adv Gastroenterol. 2018;11:1756283X17750355. https://doi.org/10.1177/1756283X17750355.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Torres J., Bonovas S., Doherty G. et al. ECCO Guidelines on Therapeutics in Crohn’s Disease: Medical Treatment. J Crohns Colitis. 2020;14(1):4–22. https://doi.org/10.1093/ecco-jcc/jjz180.</mixed-citation></ref></ref-list></back></article>
