REMEDIUMREMEDIUM1561-59362658-3534Joint-Stock Company Chicot186410.32687/1561-5936-2026-30-1-64-69Original ArticleCorrelation and regression models as a tool for forming the design basis of pharmaceutical development aspectsKulikovaAlexandra M.aleksandrakulikova2023@mail.ruBrkichGalina E.brkich_g_e@staff.sechenov.ruKuznetsovAndrey O.kuznetsov_a_o@staff.sechenov.ruDoctor. Reddis Laboratories, Moscow, RussiaSechenov First Moscow State Medical University, Moscow, Russia30032026301646923032026Copyright © 2026,2026The aim of this study was to examine the use of correctness-regression mathematical models for generating a design space at the stages of pharmaceutical drug development.quality through designcorrelation-regression modelspharmaceutical developmentdesign spaceQuality by Designкорреляционно-регрессионные моделифармацевтическая разработкапроектное поле1.Montgomery D. C. Design and analysis of experiments. 9th ed. Hoboken: Wiley; 2017.2.Eriksson L., Johansson E., Kettaneh-Wold N., et al. Design of experiments: principles and applications. Umeå: Umetrics Academy; 2008.3.Box G. E.P., Draper N. R. Empirical model-building and response surfaces. New York: Wiley; 1987.4.Myers R. H., Montgomery D. C., Anderson-Cook C. M. Response surface methodology: process and product optimization using designed experiments. 4th ed. Hoboken: Wiley; 2016.5.Lundstedt T., Seifert E., Abramo L., et al. Experimental design and optimization. Chemom Intell Lab Syst. 1998;42:3—40.6.Zyryanov O. A., Brkich G. E., Pyatigorskaya N. V., et al. Planning of experiment in pharmaceutical development: textbook. Moscow; 2024. 124 p. (In Russ.)