REMEDIUMREMEDIUM1561-59362658-3534Joint-Stock Company Chicot169210.32687/1561-5936-2024-28-1-31-38Original ArticleMegapolis laboratory service: new approaches to managing the morbidity of the population during a pandemic based on methods of mass sequencing of the virus genomeКучерявыхЕкатерина Сергеевнаkucheryavyhes@mos.ruПанаринаЯна Сергеевнаpanarinays@mos.ruВеневцевЕвгений Олеговичvenevtseveo@mos.ruКомаровАндрей Григорьевичkomarovag@dcli.ruАксеноваЕлена Ивановнаaksenovaei2@zdrav.mos.ruРомановаВероника Алексеевнаtsibinan@zdrav.mos.ruЦибинАлександр Николаевичslutskiyea@dcli.ruСлуцкийЕгор Анатольевичshtinovaia@dcli.ruШтиноваИрина Александровнаshpakovaog@dcli.ruШпаковаОльга Геннадьевнаbeliaevaas@dcli.ruБеляеваАнастасия Степановна011Government of Moscow, Moscow, RussiaDiagnostics center (Center of the laboratory testing), Moscow, RussiaResearch Institute for Healthcare Organization and Medical Management, Moscow, RussiaThe Department of Health of the City of Moscow, Moscow, Russia151220241313815102025Copyright © 2024,2024COVID-19 has become one of the most striking examples of infectious diseases that have caused a heavy burden on national health systems, which globally affected many factors of human life. The genomic sequence of RNA-containing viruses is constantly changing over time. Many new mutations in SARS-CoV-2 have been noted since its first detection in 2019. Sequencing makes it possible to identify the sequence of virus nucleotides, including new mutations. Rapid monitoring of the evolution of the virus and populations of circulating strains is a necessary step in understanding the biological properties of new virus variants and the dynamics of their transmission. Such information is important for public health services and the development of anti-epidemic measures that affect human well-being, life expectancy, and the countrys economy. During the period of active spread of the new coronavirus infection in Moscow, the entire laboratory service was quickly transformed. It has become centralized, united by a digital circuit with a powerful analytical center and modern equipment. The article presents the evolution of the citys laboratory service during the pandemic, describes the key stages of development, describes the mechanisms for planning the burden on medical organizations, taking into account the dynamics of morbidity in the population of Moscow, algorithms for increasing the capacity of laboratory services, taking into account the external epidemiological situation.SARS-CoV-2 sequencingCOVID-19 pandemicmanagement solutionslaboratory servicemorbidity management in a megalopolisload planning of medical organizationsсеквенирование SARS-CoV-2пандемия COVID-19управленческие решениялабораторная службауправление заболеваемостью в мегаполисепланирование нагрузки медицинских организаций[Kaye A. D., Okeagu C. N., Pham A. D. et al. Economic impact of COVID-19 pandemic on healthcare facilities and systems: international perspectives. Best Pract. Res. Clin. Anaesthesiol. 2021;35(3):293—306. DOI: 10.1016/j.bpa.2020.11.009][Satiani B., Davis C. A. 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