REMEDIUMREMEDIUM1561-59362658-3534Joint-Stock Company Chicot169010.32687/1561-5936-2024-28-1-22-26Original ArticleMedical and social aspects of the prevalence of herpes, its treatment, including the use of photodynamic therapy, and preventionVolginValery N.001SadykovaRomina N.002SadykovaAdelia N.003Main Military Clinical Hospital named after Academician N. N. Burdenko, Moscow, RussiaN. A. Semashko National Research Institute of Public Health, Moscow, Russian FederationKazan Medical College, Kazan, Russia151220241222615102025Copyright © 2024,2024According to WHO and according to a number of foreign authors, more than 3 billion middle-aged people in the world are carriers of the herpes simplex virus type 1 (HSV-1). About half a billion people on the planet are infected with herpes simplex virus type 2 (HSV-2), the age of these people mainly corresponds to the age group from 15 to 50 years. It is known that HSV-2 more often affects women, since during sexual contact the infection is more often transmitted from man to woman. The prevalence of HSV-2 increases with age, however, adolescents often become infected with this infection. Approximately 70% of pathological conditions caused by HSV are asymptomatic or accompanied by few symptoms and may remain unrecognized. Research has shown that HSV-2 can be co-infected with the human papillomavirus (HPV), leading to an even higher risk of developing cervical cancer. According to official data, herpes cannot be completely cured; doctors’ efforts are usually aimed at treating the symptoms of HSV. A promising direction in the treatment of recurrent herpes on the lips seems to be the use of photodynamic therapy (PDT) and photobiomodulation (PBM). PDT and PBM have been shown to have good results in relieving symptoms of simple hepatitis, accelerating healing, and reducing relapse rates without side effects. Effective HSV prevention measures include screening, use of diagnostic tools, contact tracing of sexual partners, promotion of effective barrier contraception, and appropriate counseling. Currently, many new preventive and therapeutic strategies for the treatment of HSV are in development, and mechanisms of drug resistance and associated mutations in the viral genome are being studied.herpesherpetic diseaseherpes simplex virusoral herpesgenital herpesprevalencetreatmentphotodynamic therapypreventionгерпесгерпетическая болезньвирус простого герпесаоральный герпесгенитальный герпесраспространённостьлечениефотодинамическая терапияпрофилактика[Ministry of Health of the Russian Federation. Herpes simplex (HS) in adults: clinical recommendations. ICD 10: B00/A60. Moscow; 2016.][Moscow Department of Health. Herpes simplex. Cytomegalovirus infection: Guidelines No. 9. Moscow; 2016. 16 p.][Van Wagoner N., Qushair F., Johnston C. Genital Herpes Infection: Progress and Problems. Infect. Dis. Clin. North Am. 2023;37(2):351—367. DOI: 10.1016/j.idc.2023.02.011][Mangione C. M., Barry M. J., Nicholson W. K. et al. Serologic screening for genital herpes infection: US Preventive Services Task Force Reaffirmation Recommendation Statement. JAMA. 2023;329(6):502—507. DOI: 10.1001/jama.2023.0057][Omarova S., Cannon A., Weiss W. et al. Genital Herpes simplex virus — an updated review. Adv. Pediatr. 2022;69(1):149—162. DOI: 10.1016/j.yapd.2022.03.010][Tuddenham S., Hamill M. M., Ghanem K. G. Diagnosis and treatment of sexually transmitted infections: a review. JAMA. 2022;327(2):161—172. DOI: 10.1001/jama.2021.23487][Malik S., Sah R., Ahsan O. et al. Insights into the novel therapeutics and vaccines against Herpes simplex virus. Vaccines (Basel). 2023;11(2):325. DOI: 10.3390/vaccines11020325][Sibley D., Larkin D. F. P. Update on Herpes simplex keratitis management. Eye (Lond). 2020;34(12):2219—2226. DOI: 10.1038/s41433-020-01153-x][Lorzadeh N., Kazemirad Y., Kazemirad N. Treatment of genital herpes using olive leaf extract. Clin. Case Rep. 2020;9(2):986—989. DOI: 10.1002/ccr3.3723][Mathew Jr J., Sapra A. Herpes Simplex Type 2. Treasure Island; 2023.][Sausen D. G., Shechter O., Gallo E. S. et al. Herpes Simplex Virus, Human Papillomavirus, and cervical cancer: overview, relationship, and treatment implications. Cancers (Basel). 2023;5(14):3692. DOI: 10.3390/cancers15143692][Piret J., Boivin G. Immunomodulatory Strategies in Herpes Simplex Virus Encephalitis. Clin. Microbiol. Rev. 2020;33(2):e00105—e00119. DOI: 10.1128/CMR.00105—19][Johnston C. Diagnosis and management of genital herpes: key questions and review of the evidence for the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines. Clin. Infect. Dis. 2022;74(2):S134—S143. DOI: 10.1093/cid/ciab1056][Cole S. Herpes simplex virus: epidemiology, diagnosis, and treatment. Nurs. Clin. North Am. 2020;55(3):337—345. DOI: 10.1016/j.cnur.2020.05.004][Workowski K. A., Bachmann L. H., Chan P. A. et al. Sexually transmitted infections treatment guidelines, 2021. MMWR Recomm. Rep. 2021;70(4):1—187. DOI: 10.15585/mmwr.rr7004a1][Patel R., Kennedy O. J., Clarke E. et al. 2017 European guidelines for the management of genital herpes. Int. J. STD AIDS. 2017;28(14):1366—1379. DOI: 10.1177/0956462417727194][Majewska A., Mlynarczyk-Bonikowska B. 40 years after the registration of acyclovir: do we need new anti-herpetic drugs? Int. J. Mol. Sci. 2022;23(7):3431. DOI: 10.3390/ijms23073431][Elebeedy D., Ghanem A., Aly S. H. et al. Synergistic antiviral activity of Lactobacillus acidophilus and Glycyrrhiza glabra against Herpes Simplex-1 Virus (HSV-1) and Vesicular Stomatitis Virus (VSV): experimental and In Silico insights. BMC Microbiol. 2023;23(1):173. DOI: 10.1186/s12866-023-02911-z][Kituashvili T. A., Kvirkvelia V. G., Galdava G. G., Archvadze N. G. Efficacy of Lazolex® gel in the treatment of Herpes simplex mucocutaneous infections and the prevention of recurrences: a pilot study. Can. J. Infect. Dis. Med. Microbiol. 2022;2022:4413679. DOI: 10.1155/2022/4413679][Khalil M., Hamadah O. Association of photodynamic therapy and photobiomodulation as a promising treatment of Herpes labialis: a systematic review. Photobiomodul. Photomed. Laser Surg. 2022;40(5):299—307. DOI: 10.1089/photob.2021.0186][Barros A. W.P., Sales P. H.D.H., Silva P. G.B. et al. Is low-level laser therapy effective in the treatment of herpes labialis? Systematic review and meta-analysis. Lasers Med. Sci. 2022;37(9):3393—3402. DOI: 10.1007/s10103-022-03653-6][Schalkwijk H. H., Snoeck R., Andrei G. Acyclovir resistance in herpes simplex viruses: prevalence and therapeutic alternatives. Biochem. Pharmacol. 2022;206:115322 DOI: 10.1016/j.bcp.2022. 115322][Burrel S., Topalis D., Boutolleau D. Herpes simplex virus resistance to antivirals. Virologie (Montrouge). 2020;24(5):325—342. DOI: 10.1684/vir.2020.0864]