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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher">РЕМЕДИУМ</journal-id><journal-title-group><journal-title>РЕМЕДИУМ</journal-title></journal-title-group><issn publication-format="print">1561-5936</issn><issn publication-format="electronic">2658-3534</issn><publisher><publisher-name>Joint-Stock Company Chicot</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1585</article-id><article-id pub-id-type="doi">10.32687/1561-5936-2023-27-1-86-91</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>История опиоидной эпидемии в США</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="eastern" xml:lang="ru"><surname>Хабибова</surname><given-names>Марта Ринатовна</given-names></name><bio></bio><email>001</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="eastern" xml:lang="ru"><surname>Мезенцева</surname><given-names>Екатерина Сергеевна</given-names></name><bio></bio><email>002</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff id="aff-1">Пермская государственная фармацевтическая академия, Пермь, Россия</aff><pub-date date-type="epub" iso-8601-date="2023-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2023</year></pub-date><issue>1</issue><fpage>86</fpage><lpage>91</lpage><history><pub-date date-type="received" iso-8601-date="2025-10-09"><day>09</day><month>10</month><year>2025</year></pub-date></history><permissions><copyright-statement>Copyright © 2023, АО "Шико"</copyright-statement><copyright-year>2023</copyright-year></permissions><abstract>В статье рассматривается история применения опиоидных препаратов и злоупотребления ими, анализируются и структурируются данные об опиоидном кризисе (опиоидной эпидемии) в США. История опиоидного кризиса авторами разделена на три волны, каждая из которых связана с тем или иным опиоидным препаратом (оксикодон, героин, фентанил).</abstract><kwd-group xml:lang="en"><kwd>opioids, opioid epidemic, opioid crisis, fentanyl, morphine, opium, drug addiction</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>опиоиды</kwd><kwd>опиоидная эпидемия</kwd><kwd>опиоидный кризис</kwd><kwd>фентанил</kwd><kwd>морфин</kwd><kwd>опий</kwd><kwd>наркотическая зависимость</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Moosavyzadeha A., Ghaffarib F., Mosavatc S. H. et al. The medieval Persian manuscript of Afyunieh: the ﬁrst individual treatiseon the opium and addiction in history. J. Integrat. Med. 2018; 16(2): 77—83. doi: 10.1016/j.joim.2018.02.004</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Nesměrák K., Štícha M., Belianský M., Červený V. 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