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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher">REMEDIUM</journal-id><journal-title-group><journal-title>REMEDIUM</journal-title></journal-title-group><issn publication-format="print">1561-5936</issn><issn publication-format="electronic">2658-3534</issn><publisher><publisher-name>Joint-Stock Company Chicot</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1294</article-id><article-id pub-id-type="doi">10.21518/1561-5936-2018-9-34-38</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Does the future lie with infusion hepatoprotection?</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Prozherina</surname><given-names>Julia</given-names></name><bio></bio><email>noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Shirokova</surname><given-names>Irina</given-names></name><bio></bio><email>noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff id="aff-1">Remedium</aff><pub-date date-type="epub" iso-8601-date="2018-12-09" publication-format="electronic"><day>09</day><month>12</month><year>2018</year></pub-date><issue>9</issue><fpage>34</fpage><lpage>38</lpage><history><pub-date date-type="received" iso-8601-date="2022-03-18"><day>18</day><month>03</month><year>2022</year></pub-date></history><permissions><copyright-statement>Copyright © 2018,</copyright-statement><copyright-year>2018</copyright-year></permissions><abstract>Hepatoprotectors are one of the important categories of drugs prescribed to patients with acute and severe conditions accompanied by impairment of the liver function. In view of the importance of this problem, at the end of 2017 the Government of the Russian Federation approved a new list of vital and essential medicinal products for human use for 2018, which included the original drug developed by the Russian researchers - the infusion hepatoprotector Remaxol®.</abstract><kwd-group xml:lang="en"><kwd>liver damage</kwd><kwd>infusion hepatoprotection</kwd><kwd>hypoxia</kwd><kwd>Remaxol®</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>поражение печени</kwd><kwd>инфузионная гепатопротекция</kwd><kwd>гипоксия</kwd><kwd>Ремаксол®</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Балукова Е.В. с соавт. Поражения печени различного генеза (токсического, лекарственного, дисметаболического): от этиологической гетерогенности к единой унифицированной терапии пациентов. РМЖ. Медицинское обозрение, 2018, 1(I): 35-40.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Ильченко Л.Ю., Оковитый С.В. Ремаксол: механизмы действия и применение в клинической практике. Архивъ внутренней медицины, 2016, 2(28): 16-21.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Место гепатопротекторов в сопровождающей терапии онкологических заболеваний. XXI Российский онкологический конгресс. Эффективная фармакотерапия, 2018, 5.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Новый инфузионный гепатопротектор Ремаксол. Поликлиника, 2012, 4. востребованных брендов (рис. 3). По данным компании IQVIA, по итогам 2017 г. было реализовано свыше 574 тыс. упаковок препарата Ремаксол® на сумму более 201 млн руб. в ценах закупки.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Куркина И.А., Маевская М.В., Тихонов И.Н., Зозуля В.Н., Лещенко В.И. Инфузионная терапия при хронических заболеваниях печени. Рос. Журн. гастроэнтерол. Гепатол. колопроктол., 2018, 28(3): 81-87.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Zhang Q, White H.M. Regulation of inflammation, antioxidant production, and methyl-carbon metabolism during methionine supplementation in lipopolysaccharide-challenged neonatal bovine hepatocytes. J Dairy Sci, 2017, 100(10).</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Gomez G, Sitkovsky MV. Differential requirement for A2a and A3 adenosine receptors for the protective effect of inosine in vivo. Blood, 2003, 102: 4472-4478.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Postic C. Therapeutic Potential of Nicotinamide Adenine Dinucleotide for Nonalcoholic Fatty Liver Disease. Hepatology, 2016. 63(4).</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Инструкция по применению к препарату Ремаксол.</mixed-citation></ref></ref-list></back></article>
