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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher">REMEDIUM</journal-id><journal-title-group><journal-title>REMEDIUM</journal-title></journal-title-group><issn publication-format="print">1561-5936</issn><issn publication-format="electronic">2658-3534</issn><publisher><publisher-name>Joint-Stock Company Chicot</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1278</article-id><article-id pub-id-type="doi">10.21518/1561-5936-2018-7-8-30-40</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Medical information system's Big Data Analytics based on Cluster analysis: patients with Diabetes Mellitus type 1</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Minushkina</surname><given-names>L. O.</given-names></name><bio></bio><email>noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Kolesnichenko</surname><given-names>O. YU.</given-names></name><bio></bio><email>noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Mazelis</surname><given-names>A. L.</given-names></name><bio></bio><email>noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Soldatov</surname><given-names>D. A.</given-names></name><bio></bio><email>noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Kolesnichenko</surname><given-names>YU. YU.</given-names></name><bio></bio><email>noemail@neicon.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Martynov</surname><given-names>A. V.</given-names></name><bio></bio><email>noemail@neicon.ru</email><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Pulit</surname><given-names>V. V.</given-names></name><bio></bio><email>noemail@neicon.ru</email><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Dolzhenkov</surname><given-names>A. N.</given-names></name><bio></bio><email>noemail@neicon.ru</email><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Grigorevsky</surname><given-names>I. N.</given-names></name><bio></bio><email>noemail@neicon.ru</email><xref ref-type="aff" rid="aff-7"/><xref ref-type="aff" rid="aff-8"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Mazelis</surname><given-names>L. S.</given-names></name><bio></bio><email>noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff id="aff-1">Central State Medical Academy at the Department of Presidential Affairs</aff><aff id="aff-2">Institute of sociology, psychology and humanities</aff><aff id="aff-3">I.M. Sechenov First Moscow State Medical University</aff><aff id="aff-4">Vladivostok State University of Economics and Service</aff><aff id="aff-5">4Uzgraph</aff><aff id="aff-6">SP.ARM</aff><aff id="aff-7">Aylamazyan Program Systems Institute of Russian Academy of Sciences</aff><aff id="aff-8">National Supercomputing Technology Platform</aff><pub-date date-type="epub" iso-8601-date="2018-12-07" publication-format="electronic"><day>07</day><month>12</month><year>2018</year></pub-date><issue>7-8</issue><fpage>30</fpage><lpage>40</lpage><history><pub-date date-type="received" iso-8601-date="2022-03-18"><day>18</day><month>03</month><year>2022</year></pub-date></history><permissions><copyright-statement>Copyright © 2018,</copyright-statement><copyright-year>2018</copyright-year></permissions><abstract>Cluster analysis of medical information system’s records used to find direct and indirect indications to differences in the hospital management of patients with Diabetes Mellitus type 1, according to the prescribed diagnostic examinations and surgery. This approach allows to investigate disease’s pathogenetic mechanisms and provides predictive analytics of patients flow for more personalized treatment. Five clusters have been identified. Open international genetic databases were analyzed additionally in terms of some key pathogenesis molecular complexes. All data was compared and connected continuum of the Diabetes Mellitus type 1 pathogenetic cascade was proposed.</abstract><kwd-group xml:lang="en"><kwd>Cluster analysis</kwd><kwd>Diabetes Mellitus type 1</kwd><kwd>pathogenetic cascade continuum</kwd><kwd>medical information system</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>кластерный анализ</kwd><kwd>СД 1</kwd><kwd>континуум патогенетического каскада</kwd><kwd>медицинские информационные системы</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Колесниченко О.Ю., Мазелис АЛ., Николаев А.Э., Мартынов А.В., Пулит В.В., Смородин Г.Н., Колесниченко Ю.Ю. 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